context from the 1970s till the mid 1990s, hepatitis b was the most common etiological factor for hepatocellular carcinoma (hcc) in pakistan. afterwards, a shift in hcc etiology was observed with a steady rise in hepatitis c virus (hcv) related hcc cases. hcv-3a, which is the most prevalent genotype, is also most frequent in hcv related hcc. there was an increase in the proportion of non-b non-...

background hepatocellular carcinoma (hcc) is the fifth most common fatal cancer and an important healthcare problem worldwide. there are many studies describing the prognostic and predictive effects of epidermal growth factor receptor 2 (c-erb-b2) and epidermal growth factor receptor 1 (egfr), transmembrane tyrosine kinases that influence cell growth and proliferation in many tumors. objectives...

at necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. in solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...

conclusions we showed that in treatment of patients with unresectable hepatocellular carcinoma, tace significantly improved the disease and the overall survival rate. also, we introduce the tumor size, serum alp level, and number of liver involved segments as prognostic factors of the procedure. finally, tace can be recommended as the initial treatment for unresectable hcc patients. background ...

conclusions plasma opn is comparable to afp as a diagnostic marker and is related to the severity of liver involvement in hcc patients. plasma opn is of diagnostic potential value in nafld. background osteopontin (opn) is a secreted glycoprotein and is frequently associated with various tumors. objectives we sought to investigate the clinical usefulness of the level of plasma opn, compared to α...

context viral hepatitis and the consumption of alcohol are recognized as important reasons for the development of liver disease throughout the world. it would also seem that chronic alcoholism causes more severe and rapid progression of liver disease in patients with chronic hepatitis c, leading to more frequent liver cirrhosis and hepatocellular carcinoma. evidence acquisition the data for thi...

background: telomerase activity increases in cancer cells. bcl-2 is an antiapoptotic factor that its concentration grows in many cancer cells including hepatocellular carcinoma cells. in this study, an attempt was made to investigate the effects of a new synthetic compound, platinum azidothymidine (pt-azt) on treatment of rats with hepatocellular carcinoma (hcc) and to compare its effects with ...